Despite the blow that will come when House of Fraser closes its doors, he said other firms are looking at Carlisle and what it has to offer.
Mr Glover believes the former Hoopers building on Castle Street, which is back on the market for £1.5m, could lend itself to a number of uses, including retail, residential and business space.
Economy drivers already in place include The Old Fire Station arts and performance venue and the University of Cumbria, which has encouraged more people to study closer to home and has drawn in students from elsewhere, with some staying after they graduate.
Mr Glover added: “We have got a growing economy here. Yes there are challenges but we are recognised as being the place that drives the regional economy.
“We are a proactive council.
“We drive change, we don’t just react to it, so we can make things happen.
“You might think we are not as big as some of those other cities but we are now recognised as making a significant contribution.”